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Metabolic Study of Resveratrol in Rat Biosamples by UPLC-Q-TOF/MS

Author(s): Miao Qiao, Chenxi Guang, Liqin Ding, Xuliu Shi, Liwei Chai, Xinchi Feng

Abstract

Resveratrol is a polyphenol derived from a variety of food and beverages, which has been reported to possess diverse pharmacological activities. An ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) method was established to figure out the metabolic profiles of resveratrol in rat biological samples after oral administration. According to the results, 21 resveratrol-related metabolites in rat biosamples were found after oral administration. As far as we know, 14 of these metabolites (M3 to M10, M13, M16, M17 and M21) have not been reported previously. Furthermore, glucuronide conjugation, sulfate conjugation, methylation, hydroxylation and reduction were the main metabolic pathways. Besides, the hydroxylated product was also detected in rat liver microsome. The results may be conducive to a better understanding the metabolic mechanism of resveratrol and provide helpful chemical information for further pharmacological and action mechanism studies of resveratrol.

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